Synthesis and spectral characterization of esomeprazole sodium Polymorphic form

Regulatory authorities throughout the world require that all possible crystalline forms of the same active drug compound be synthesized and characterized as completely as possible. There is thus a continuing need to prepare new polymorphic forms of pharmacologically active compounds. Therefore it is need for preparation of highly pure polymorphic form N esomeprazole sodium by a repeatable process which guarantees stable physical form. Despite the fact that there are numerous known forms of omeprazole, the need continues to exist for novel, pharmaceutically-acceptable forms of omeprazole which may exhibit improved pharmacokinetic and metabolic properties and/or which may result in an improved therapeutic profile. Herein, we report our synthetic study of esomeprazole sodium Polymorphic form.